Multiresponsive Properties of Triple‐Shell Architectures with Poly(N,N‐diethylaminoethyl methacrylate), Poly(N‐vinylcaprolactam), and Poly(N,N‐dimethylaminoethyl methacrylate) as Building Blocks

Abstract

AbstractTriple‐shell architectures, consisting of poly[(N,N‐diethylaminoethyl methacrylate)‐block‐(N‐vinylcaprolactam)‐block‐(N,N‐dimethylaminoethyl methacrylate)] triblock copolymers, are obtained by sequential reversible addition–fragmentation chain transfer polymerizations, using a terminal‐modified hyperbranched poly(β‐cyclodextrin) core as a macro chain transfer agent. UV‐vis spectroscopy results indicate that the triple‐shell architectures possess one pH response at pH 12.5 in aqueous solution at room temperature, followed by double‐temperature‐ responsiveness between 33 °C and 36 °C. The special multiresponsive properties are further confirmed by investigating the controlled release behavior of the resulting polymers using metronidazole as a model drug.