Abstract
The resolution and accuracy of the 3D images obtained with single particle reconstruction (SPR) highly depend on the number and signal to noise ratio of the particle images. The maximum a posteriori probability expectation maximization (MAPEM) reconstruction methods have been successful in suppressing noise and compensating for the limited angular sampling. This paper presents a multiresolution MAPEM (mMAPEM) method to improve the resolution and accuracy of the 3D images of the symmetrical particles reconstructed using SPR. The method utilizes the median root prior and the symmetry information about the reconstructed structure in the image domain. The method was compared with the conventional Fourier Reconstruction (FR) method using phantom and experimental datasets for different noise levels and projection angle sampling conditions. The numerical and visual assessment of the reconstruction results demonstrate that the mMAPEM method provides more accurate results than FR.
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