Abstract
Two sets of heterofunctional dendritic frameworks displaying an inversed and exact number of ene and azide groups have successfully been synthesized and post-functionalized with biorelevant molecules. Their facile scaffolding ability enabled the fabrication of soft and azide functional dendritic hydrogels with modulus close to muscle tissue. The dendritic scaffolds are furthermore shown to be promising primers for the development of novel bone fracture stabilization adhesives with shear strengths succeeding commercial Histroacryl®.
Highlights
Multipurpose heterofunctional dendritic scaffolds as crosslinkers towards functional soft hydrogels and implant adhesives in bone fracture applications†
Heterofunctional dendrimers, being synthetically one of the most challenging macromolecular scaffolds to isolate, have been reported via elegant click strategies.[7,8,9,10,11,12]. Their globular conformation coupled with the exact number of orthogonal functional groups distributed on the dendritic framework makes these structures promising aKTH Royal Institute of Technology, Polymer and Fiber Technology, Division of Coating Technology, Stockholm, Sweden
Heterofunctional dendritic (HFD) scaffolds were sought out as promising monodisperse materials that deliver an exact number orthogonal groups.[8]
Summary
Multipurpose heterofunctional dendritic scaffolds as crosslinkers towards functional soft hydrogels and implant adhesives in bone fracture applications†.
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