Multi-projection based fluorescence optical tomography using a hand-held probe based optical imager

Abstract

Hand-held based optical imagers have become a new research interest for its maximum patient comfort, less bulky instrument and potential for clinical translation towards breast cancer diagnostics. However, its ability for optical tomography is either limited by depth recovery since only reflectance measurements were obtained using a hand-held design for imaging. In this study, we introduced a self-guided multi-projection technique, which can take advantage of potential portability of hand-held probe based system, towards improvement of target depth recovery during fluorescence optical tomography studies.