MULTIPOTENT MESENCHYMAL STROMAL CELLS OF BONE MARROW IN THERAPY OF CHRONIC INFLAMMATION OF THE MURINE OVARIES

Abstract

Today the cause of reproductive disorders in women frequently is the inflammation of pelvic organs. Chronic inflammation of the ovaries (oophoritis) is a common disease, accompanied by various gynecological dis-orders, and occurs independently as well. According to the Ministry of Healthcare of Ukraine, the frequency of inflammatory diseases of pelvic organs in the structure of pathology in gynecological practice reaches 60–65% [1]. As a consequence, prolonged and recurrent course of the disease in 60% of cases can lead to infertility. It should be noted that oophoritis largely occurs due to the presence of primary immunodeficiency, which facilitates the transition of acute inflammatory process at a chronic stage. At the same time prolonged inflammation causes a decrease in immunological reactivity of an organism. In chronic inflammatory processes the change of cytokine profile is natural, which leads to statistically significant decline in the efficiency of infertility treatment [2].During the treatment of uterine appenda ges’ inflammation the patients receive medicines of almost all pharmacological groups, inclu-ding the reserve antibiotics and non-steroidal anti-inflammatory drugs that lead to forma-tion of antibiotic-resistant strains, activation of opportunistic flora, increased allergization, dysfunction of the immune system [1, 2]. As a rule the effectiveness of oophoritis treatment is low, and therefore the researches of alternative methods of treatment are intensively carried out, particularly the use of cell therapy. Taking into account the abovementioned it is reasonable to search for new medicines having the ability to impact on the chronic phase