Multipoint mapping for imaging of semi-solid materials

Abstract

Multipoint k-space mapping is a hybrid between constant-time (single-point mapping) and spin-warp imaging, involving sampling of a k-line segment of r points per TR cycle. In this work the method was implemented for NMR imaging of semi-solid materials on a 400 MHz micro-imaging system and two different k-space sampling strategies were investigated to minimize the adverse effects from relaxation-induced k-space signal modulation. Signal attenuation from T 2 decay results in artifacts whose nature depends on the k-space sampling strategy. The artifacts can be minimized by increasing the readout gradient amplitude, by PSF deconvolution or by oversampling in readout direction. Finally, implementation of a T 2 selective RF excitation demonstrates the feasibility of obtaining short-T 2 contrast even in the presence of tissues with long-T 2. The method’s potential is illustrated with 3D proton images of short-T 2 materials such as synthetic polymers and bone.