Abstract
The transport of free glucalogues across the mucosal pole of hamster small intestine is carried out by (at least) two transport systems, one of which is common to glucose, galactose, 6-deoxyglucose and 3-methylglucose, whereas the order is essentially specific for glucose and galactose, among the monosaccharides tested. This was shown by: 1. 1. The dependence of the unidirectional medium-mucosa flux on the substrate concentration which is described by a single horizontal hyperbola in the cases of 6-deoxyglucose and of 3-O- methylglucose , but by the sum of two such hyperbolas in the cases of both glucose and galactose. 2. 2. The mutual inhibition among glucalogues and the inhibition by arbutin, which are best described by the existence of two carriers, as given above: 3. 3. The difference in the absorption of glucose and galactose in baby hamsters as compared with adult hamsters. Both systems are Na +-dependent and (to a different degree) phlorizin-sensitive. Neither is identical with the fructose transport system.
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