Abstract
Introduction. Colorectal cancer is one of the most common cancers worldwide. In the Republic of Kazakhstan, over the past decade, the incidence rates of colon and rectal cancers have increased by 23 % and 17 %, respectively. Although colorectal cancer screening rates have increased over time, it is necessary to identify new serum markers for early detection and prognosis of this cancer. The aim of the study was to evaluate the diagnostic value of serum biomarkers for colorectal cancer. Material and Methods . Biomarkers were studied by immunofluorescence method using xMap technology, which included simultaneous immunofluorescence determination on magnetic spheres CA125, CA15–3, CA19–9, CEA, CYFRA21–1, sFAS, sFasL, HE4, Osteopontin, VEGF-A, pd-L1. Results . The study showed no significant differences in the levels of markers between healthy subjects (control group) and patients with bowel diseases. In cancer patients, СEA and OpN markers increased with increasing tumor stage, and were significantly higher than those observed in patients with bowel diseases and controls. The CA125 marker was significantly higher in patients with stage IV cancer then in patients with I–III stages. Conclusion . Our study revealed that the new pd-L1 marker can serve as a significant biomarker for colorectal cancer.
Highlights
Colorectal cancer is one of the most common cancers worldwide
Colorectal cancer screening rates have increased over time, it is necessary to identify new serum markers for early detection and prognosis of this cancer
Biomarkers were studied by immunofluorescence method using XMap technology, which included simultaneous immunofluorescence determination on magnetic spheres CA125, CA15–3, CA19–9, CEA, CYFRA21–1, sFAS, sFasL, HE4, Osteopontin, VEGF-A, PD-L1
Summary
Колоректальный рак (КРР) занимает одно из ведущих мест в структуре онкологической заболеваемости, в том числе в азиатских странах. Несмотря на действующие программы скрининга колоректального рака, продолжается поиск новых, в том числе сывороточных, маркеров для ранней диагностики, а у пациентов с выявленным КРР – панелей маркеров для прогноза течения заболевания. Целью исследования является изучение диагностической ценности и динамики сывороточных биомаркеров у больных КРР разных стадий. При КРР выявлена статистически значимая зависимость уровня только 2 биомаркеров – CEA и ОПН – от стадии заболевания. У больных КРР IV стадии наблюдается значимое повышение CA125 по сравнению с новообразованиями I–III стадий. Как CA19–9, HE-4, CA15–3, CYFRA 21–1, наряду с CEA, могут быть предложены для применения в комплексной диагностической панели. Полученные результаты позволяют сделать вывод о диагностических перспективах маркера PD-L1 при колоректальном раке. Ключевые слова: колоректальный рак, онкомаркеры, CEA, PD-L1, остеопонтин
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