Abstract
Multiple-system atrophy is a neurodegenerative disease that involves various combinations of parkinsonism, ataxia, corticospinal motor signs, and postural hypotension or urinary incontinence (Shy-Drager syndrome). The pathological hallmark of the disease is the presence of glial and neuronal cytoplasmic inclusions, shown by modified Bielschowsky silver impregnation and, to a limited extent, with antisera to ubiquitin or αB-crystallin. 1 Lantos PL Papp MI Cellular pathology of multiple system atrophy: a review. J Neurol Neurosurg Psychiatr. 1994; 57: 129 Crossref PubMed Scopus (137) Google Scholar We show that glial cytoplasmic inclusions and degenerating neurites in multiple-system atrophy are strongly immunopositive for α-synuclein, a presynaptic protein present in brainstem and cortical Lewy bodies and related neurites in idiopathic Parkinson's disease and dementia with Lewy bodies, 2 Spillantini MG Schmidt ML Lee VM-Y et al. α-Synuclein in Lewy bodies. Nature. 1997; 388: 839 Crossref PubMed Scopus (5906) Google Scholar and, in a mutated form, in some cases of familial Parkinson's disease. 3 Polymeropoulos MH Lavedan C Leroy E et al. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science. 1997; 276: 2045 Crossref PubMed Scopus (6466) Google Scholar
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