Multiple thrombophilic risk markers in patients ≺65years of age with retinal vein occlusion

Abstract

The potential impact of multiple thrombophilic defects on retinal venous occlusive (RVO) diseases with regard to age and various risk factors has not been studied extensively. In aretrospective, multicenter study, thrombophilia data of 128 patients <65years of age with RVO and 110 healthy subjects were evaluated. The main measure outcome was the prevalence of multiple thrombophilic disorders. Multiple thrombophilic defects were significantly more prevalent among RVO patients (18.0%) than among controls (1.8%; P< 0.0001). We identified factor VIII elevation, elevated lipoprotein(a) plasma levels and resistance to activated proteinC as the most prevalent combined disorders. FactorXII deficiency and prothrombin mutation G20210A were found to be isolated thrombophilic risk factors. Multiple thrombophilic defects were significantly associated with RVO recurrence (P= 0.008). Multiple thrombophilic disorders are associated with the development of RVO among patients younger than 65years of age. Moreover, our results suggest that patients with RVO associated with underlying combined thrombophilic defects are at increased risk for RVO recurrence. Further studies are required to analyze whether the diagnosis of combined thrombophilic defects among RVO patients could be apredictor for RVO recurrence.