Multiple Tachykinins and Calcitonin Gene-Related Peptide (CGRP) in Capsaicin-Sensitive Nerves of Sympathetic Ganglia

A. Saria,J. M. Lundberg,E. Theodorsson-Norheim,G. Skofitsch,R. C. Ma,R. Amann,N. J. Dun

doi:10.1007/978-1-4612-4672-5_82

Multiple Tachykinins and Calcitonin Gene-Related Peptide (CGRP) in Capsaicin-Sensitive Nerves of Sympathetic Ganglia

A. Saria, J. M. Lundberg + Show 5 more

https://doi.org/10.1007/978-1-4612-4672-5_82

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Publication Date: Jan 1, 1987

Citations: 2

Affiliation: University of Graz, Karolinska University Hospital

#Non-cholinergic Slow Excitatory Postsynaptic Potential #Calcitonin Gene-Related Peptide + Show 8 more

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Abstract

Recent evidence suggests the presence of multiple tachykinins, i.e. substance P (SP), neurokinin A (NKA), neuropeptide K (NPK) and an eledoisin-like peptide (ELE) in capsaicin-sensitive primary afferent neurons [1]. Some of these neurons also contain calcitonin gene-related peptide (CGRP) [2]. Release of SP from collateral branches of primary afferents terminating in prevertebral ganglia [3] appears to be responsible for the generation of a non-cholinergic slow excitatory postsynaptic potential (EPSP) [4,5,6]. Here we present biochemical and electrophysiological studies on guinea-pig sympathetic ganglia.

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