Multiple strategy for antibacterial effect via copper porphyrin doping polyphenolic aldehydes based covalent organic framework

Abstract

Microbial infections continue to be one of the cosmopolitan safety hazards to humankind. To achieve effective sterilization, it is urgent to develop non-antibiotic strategies or integrating multiple antimicrobial methods. Organic photo-antimicrobials (OPAMs) has attracted attention in fighting against bacteria by reactive oxygen species (ROS) or heat without triggering drug resistance. In our work, a copper-porphyrin doping donor-acceptor (D-A) type covalent organic framework (COF), named CTF-BTA2OH-Por(Cu), is constructed to achieve synergistic antibacterial effects by ROS generation and protein degradation. Copper-porphyrin doping improves ROS generation of D-A COF, showing great photocatalytic antibacterial activity (>90% within 1h). Additionally, the polyphenolic aldehydes of BTA2OH can interact with protein strongly and cause degradation, resulting inhibition of bacteria growth without light. Thus, CTF-BTA2OH-Por(Cu) showed antibacterial activity under both light and dark conditions. These findings give inspiration for COF multifunctional design for antimicrobials strategy and its application in supplies anti-infection or preservation.