Multiple spike time patterns occur at bifurcation points of membrane potential dynamics

Abstract

Event Abstract Back to Event Multiple spike time patterns occur at bifurcation points of membrane potential dynamics J. Vincent Toups1, Jean-Marc Fellous2, Peter J. Thomas3*, Terrence J. Sejnowski4, 5, 6 and Paul H. Tiesinga1, 7 1 University of North Carolina at Chapel Hill, United States 2 University of Arizona, United States 3 Case Western Reserve University , Department of Mathematics, United States 4 Salk Institute, United States 5 HHMI, United States 6 University of California at San Diego, United States 7 Radboud University, Netherlands The response of a neuron to fluctuating current injected in vitro typically elicits a reliable and precisely timed sequence of action potentials when the same waveform is repeated. The effects that different stimulus conditions occurring in vivo might have on the reproducibility of output spike times remains an open question. To address this question, we somatically injected an aperiodic current into cortical neurons in vitro and varied the amplitude of the fluctuations and the constant pedestal or offset. As the amplitude of the fluctuations was increased the spike reliabilities increased and the spike times remained stable over a range of values. However, at exceptional values called bifurcation points, large shifts in the spike times were obtained in response to small changes in the stimulus amplitude. At such bifurcation points, multiple spike patterns were revealed with an unsupervised method. Increasing the current offset, which mimicked an increase in network activity, also increased the spike time reliability, but the spike times shifted earlier with increasing offset. Although the reliability was reduced at bifurcation points, the information about the stimulus time course was increased because each of the spike time patterns contained different information about the input. Conference: Computational and Systems Neuroscience 2010, Salt Lake City, UT, United States, 25 Feb - 2 Mar, 2010. Presentation Type: Poster Presentation Topic: Poster session III Citation: Toups J, Fellous J, Thomas PJ, Sejnowski TJ and Tiesinga PH (2010). Multiple spike time patterns occur at bifurcation points of membrane potential dynamics. Front. Neurosci. Conference Abstract: Computational and Systems Neuroscience 2010. doi: 10.3389/conf.fnins.2010.03.00244 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 04 Mar 2010; Published Online: 04 Mar 2010. * Correspondence: Peter J Thomas, Case Western Reserve University, Department of Mathematics, Cleveland, United States, pjthomas@cwru.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers J. Vincent Toups Jean-Marc Fellous Peter J Thomas Terrence J Sejnowski Paul H Tiesinga Google J. Vincent Toups Jean-Marc Fellous Peter J Thomas Terrence J Sejnowski Paul H Tiesinga Google Scholar J. Vincent Toups Jean-Marc Fellous Peter J Thomas Terrence J Sejnowski Paul H Tiesinga PubMed J. Vincent Toups Jean-Marc Fellous Peter J Thomas Terrence J Sejnowski Paul H Tiesinga Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.