Abstract
Multiple seborrheic keratoses in a previously irradiated site
Highlights
Breast cancer is the second most common malignancy worldwide
A case of multiple seborrheic keratoses restricted to the site of previous breast cancer radiotherapy is described
The histopathology of a lesion was compatible with the diagnosis, due to the presence of basaloid cells, hyperkeratosis, and formation of horn pseudocysts (Fig. 3)
Summary
Dear Editor, Breast cancer is the second most common malignancy worldwide. In Brazil, 59,700 new cases were estimated for 2019. A female patient, 73 years old, white, was diagnosed four years ago with invasive micropapillary carcinoma in the left breast, which required surgical intervention (quadrantectomy), chemotherapy (adriamycin, cyclophosphamide, and paclitaxel) and 30 adjuvant radiotherapy sessions. Six months ago, she noticed the onset of brownish, asymptomatic, slowly evolving papules, restricted to the skin adjacent to the surgical scar, an area previously irradiated The sign of Leser-Trélat is rare, and characterized by the abrupt eruption of multiple seborrheic keratoses, usually on the back, which may precede or occur after the diagnosis of the malignancy, especially lung and gastrointestinal adenocarcinoma.[4] The patient presented progressive lesions only at the irradiated site. Due to the presence of multiple lesions, the authors decided to excise one of them for histopathological examination, confirming the clinical diagnosis
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