Abstract
Treatment of multiple sclerosis (MS) has 2 aspects: immunomodulatory therapy (IMT) for the underlying immune disorder and therapies to relieve or modify symptoms. IMT is directed toward reducing the frequency of relapses and slowing progression. Currently, most disease-modifying agents have been approved for use only in relapsing forms of MS. Mitoxantrone (see below) is also approved for the treatment of secondary (long-term) progressive and progressive relapsing MS. People with advanced MS have severe MS symptoms. In most cases, people with advanced MS are nonambulatory. This means they cannot walk or get around without help from another person or a motorized device. Also, people at this stage have an increased risk of developing other health conditions such as osteoporosis or epilepsy.
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