Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial (MS-SMART): a multiarm phase IIb randomised, double-blind, placebo-controlled clinical trial comparing the efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis

Peter Connick,Ferran Prados Carrasco,David Macmanus,Marie Braisher,Basil Sharrack,Gina Cranswick,Sue Pavitt ,Anisha Doshi,Richard Parker ,C Wheeler-Kingshott ,Gavin Giovannoni,Floriana De Angelis,Christopher J Weir ,Roger Bastow,Frederik Barkhof,Siddharthan Chandran,Domenico Plantone,Jonathan Stutters,Moira Ross,Nevin John,Nigel Stallard,Clive Hawkins,Sébastien Ourselin ,Jeremy Chataway

doi:10.1136/bmjopen-2018-021944

Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial (MS-SMART): a multiarm phase IIb randomised, double-blind, placebo-controlled clinical trial comparing the efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis

Peter Connick, Ferran Prados Carrasco + Show 22 more

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https://doi.org/10.1136/bmjopen-2018-021944

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Journal: BMJ Open	Publication Date: Aug 1, 2018
Citations: 47	License type: open-access

Affiliation: University of Edinburgh, Multiple Sclerosis Society, University College London, National Hospital for Neurology and Neurosurgery, Royal Hallamshire Hospital, Leeds Dental Hospital, University of Leeds, Queen Mary University of London, Amsterdam UMC Location VUmc, University of Warwick, Keele University

#Percentage Brain Volume Change #Multi-Arm Trial + Show 8 more

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Abstract

IntroductionThe major unmet need in multiple sclerosis (MS) is for neuroprotective therapies that can slow (or ideally stop) the rate of disease progression. The UK MS Society Clinical Trials Network...

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