Abstract
The Multiple Sclerosis (MS) is an autoimmune and demyelinating inflammatory chronic disorder that, as it develops, gains a neurodegenerative capability...
Highlights
The Multiple Sclerosis (MS) is an autoimmune and demyelinating inflammatory chronic disorder that, as it develops, gains a neurodegenerative capability
The present study aims for the clarification of positive oligoclonal IgG bands (OCB IgG) prevalence in MS and Clinically isolated syndrome (CIS) patients and their association with the disease prognosis and conversion to CIS, it is intended to study the relation between latitude and MS and CIS patients
The articles used in this study present a population distribution with a higher number of women than men affected by MS and CIS [34,35], which meets previous investigations [1,2]
Summary
The Multiple Sclerosis (MS) is an autoimmune and demyelinating inflammatory chronic disorder that, as it develops, gains a neurodegenerative capability. Relapsing remitting MS (RRMS) it’s the most usual appearing in 85% of patients [2] It consists in the occurrence of relapses, followed by total or partial recovery, the remission period. In about 65% [1] of patients with RRMS the disease develops into secondary progressive MS (SPMS), in which the clinical episodes become more frequent, leading to axonal degeneration and the possible presentation of signs of gliosis [2]. Isolated syndrome (CIS) is defined as the first clinical episode that presents characteristics that suggest a MS diagnosis. In these episodes the optical nerve, the brainstem and the spinal cord can be affected [3]. Its importance comes from the 90% of MS cases that have presence of OCB IgG, even though this percentage can vary according to the geographic location of the patients [1,9]
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