Abstract

Although the epidemiological similarity between the two diseases is true, this thesis was not discussed extensively, perhaps because it implied that some children might have been victims of abuse, which sounds false and potentially unfair. We believe that transverse myelitis and MS are the result of an infectious disease, eventually sexually transmitted by chlamydia/gonococcus, which is caused by a subclinical bacterial urethritis/inflamatory pelvic disease (IPD) among adults. In children it is the same disease but caused by common uropathogens/enterobacteria. Both UTI and MS are much more common in girls than in boys [2, 3]. These UTIs would favor herpetic proliferation via toll-like receptors (TLRs), since the virus is endemic and always present, and it is not possible to eradicate it completely. Herpes viral load is counteracted by interferon alpha 1 (IFN alpha-1), present in different cell types, from macrophages to lymphocytes passing through endothelia and fibroblasts. Interferon alpha 1, when interacting with its specific receptors, produces in the intracellular the action of antiviral RNAse and the inhibition of viral protein synthesis

Highlights

  • We believe that transverse myelitis and multiple sclerosis (MS) are the result of an infectious disease, eventually sexually transmitted by chlamydia/gonococcus, which is caused by a subclinical bacterial urethritis/inflamatory pelvic disease (IPD) among adults

  • TLR2/4 when stimulated by lipopolysaccharides (LPS) from bacteria reduce the production of IFN alpha increasing the viral load [9, 10, 11]

  • Viral proliferation can be stimulated via LPS, ie, pathogen-associated molecular protein (PAMP), which by stimulating inflammation, by interacting with TLR2/4, would reduce IFN-alpha1 and, increase viral load

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Summary

Introduction

Jose Artur Medina Biochemical Physiopathology Medicine Faculty of University of São Paulo, Laboratory of Biochemical and Biophysical Butantan Institute, Brazil. *Corresponding Author: José Artur Medina, Pediatrician, MD degree, Doctoral student in Biochemical Physiopathology Medicine Faculty of University of São Paulo, Laboratory of Biochemical and Biophysical Butantan Institute, Brazil.

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