Abstract
Owing to recent advances in diagnostic and surgical techniques for cancer, a patient diagnosed with two or more neoplasms is not rare. We report on the case of a 58-year-old male with multiple primary malignant neoplasms, who suffered from three histological types of malignant neoplasm in six organs, namely the glottis, renal pelvis, urinary bladder, oral floor, prostate, and esophagus in chronological order. The first neoplasm was a squamous cell carcinoma of the glottis diagnosed in 2006. The second and third neoplasms were urothelial carcinomas of the right renal pelvis and urinary bladder, respectively, diagnosed in 2008. The remaining three neoplasms were diagnosed in 2010, namely a squamous cell carcinoma of the oral floor, an adenocarcinoma of the prostate, and a squamous cell carcinoma of the esophagus. The glottic cancer and esophageal cancer were treated by external radiation therapy. The malignant neoplasms of the oral floor and those which originated in the urinary tract were surgically resected. All neoplasms except the malignant neoplasm of the oral floor were well controlled. The patient died of cervical lymph node metastasis from the squamous cell carcinoma of the oral floor in January 2011. As far as we know, the present report is the first one on this combination of primary malignant neoplasms.
Highlights
Detection and development of novel treatment modalities are improving longevity of patients with cancer
The increasing possibility of suffering from multiple primary malignant neoplasms (MPMN) is emerging as a common problem for cancer survivors; Multiple primary malignant neoplasms (MPMN) were first described by Billroth et al [1]
We describe the rare case of a patient who suffered from three histological types of malignant neoplasm in six organs, namely a squamous cell carcinoma (SCC) of the glottis, oral floor, and esophagus, a urothelial carcinoma (UC) of the right renal pelvis and urinary bladder, and an adenocarcinoma (AC) of the prostate
Summary
Detection and development of novel treatment modalities are improving longevity of patients with cancer. Case presentation A 58-year-old male, a manager of a tavern, habitual drinker (one bottle of beer a day for 36 years), and heavy smoker (20 cigarettes a day for 33 years), was referred to our department for asymptomatic gross hematuria on February 2008 Two years before, he had been diagnosed with a SCC of the glottis, pT1N0M0 (stage I) which was treated by 70 Gy of external radiation therapy at the University of Tokyo Hospital. Since November 2007, he had been diagnosed with alcoholic liver cirrhosis and had received conservative medical treatment at a nearby hospital He did not have any family history of malignant neoplasms. In March 2010, 6 weeks after resection of the tumor of the oral floor, a head and neck CT scan suggested a submental lymph node swelling. As for the renal pelvic cancer and bladder cancer, immunoreactivity of p53 was weakly positive in scattered cancer cells
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