Multiple Path Particle Dosimetry Modeling Employability to Complement in-vitro Ultrafine Particle Toxicity Study

Abstract

This paper demonstrates how computationally prediction can be done on inhaled ultrafine aerosol particles that are transported, disseminated, and deposited in the respiratory tracts of laboratory mice. Poyldisperse ultrafine particles (UFP) range between 1 nm and 100 nm in diameter. Multiple Path Particle Dosimetry (MPPD), a probabilistic computational simulation software was used to mimic in-vitro experimental conditions. In this work, the physical, mechanical and electrical properties of the UFPs were used as input parameters in MPPD. Additionally, pulmonary physiologic and morphometry input variables for BALB/c mice strain were applied to the simulation. Finally, the UFP deposition results of the computational simulation study were compared with in-vitro UFP deposition trends published in scholarly journals, and fitting agreements were found. Mutually both in-silico (computational modeling) and in-vitro studies complemented each other in determining the UFP toxicity burdens in fetal mice.