Abstract
The results of short term (8-day) and longer term (28-day) pharmacokinetic studies in healthy male volunteers (n = 27) indicate that steady-state plasma bunazosin concentrations are achieved within 8 to 14 days on initiating multiple oral dose administration of a sustained-release formulation of bunazosin (Bunazosin Retard®) 6mg once daily. There is no evidence of bunazosin accumulation with multiple oral dose administration.
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