MULTIPLE ORAL CARCINOMAS IN A PATIENT WITH FANCONI ANEMIA AND A HISTORY OF HEMATOPOIETIC STEM CELL TRANSPLANATION

Abstract

Fanconi Anemia (FA) is a rare autosomal recessive genetic disorder that can cause bone marrow failure and increased risk for malignancies. Hematopoietic stem cell transplantation (HSCT) in patients with FA also increases the risk of tumors. The following reported case is of a male patient, diagnosed with AF, with a history of HSCT at 4 years of age. At 14 years old, he presented with a painless ulcerated lesion, irregular borders, 3 cm in size, on the right lateral border of the tongue with a 20-day course, associated with a submandibular lymphadenopathy. Incisional biopsy was performed, and a squamous cell carcinoma (SCC) was diagnosed. The patient underwent surgery and radiotherapy. In 2017, another ulcerated lesion was found on the left lateral border of the tongue, with hard, raised edges. After the incisional biopsy, a new SCC was reported. The patient underwent surgery and microsurgical reconstruction of the area. Due to the susceptibility to tumor development in patients with FA, periodic examinations of the oral cavity are mandatory.