Multiple omics matrix and schizophrenic biomarkers

Abstract

The etiology and pathological mechanism of schizophrenia are very complicated, and the heterogeneity of clinical manifestation and the heterogeneity of treatment reaction are also distinct. The journal of World Journal of psychiatry reported that in the past 20 years, about the schizophrenic biomarker study, either the direction of our research is wrong, or the direction is right, but the method is wrong. It is urgent to adopt new technologies to carry out study about the biomarkers of schizophrenia from multiple perspectives. It can be seen that the precise exploration of the etiology and specific pathological mechanism and therapeutic targets of schizophrenia is still a common research task of the world researchers. Compared with the research results achieved by tumor and heart disease study and the rapid development of clinical transformation, psychiatric research needs to consider other disciplines' ideas, methods and techniques to promote the research of schizophrenia. In the past 2 years, many scholars have studied schizophrenia from different perspectives. This paper reviewed the previous studies about omics matrix biomarkers study during the past two years. We briefly summarized the previous findings from the brain connectomics, genomics, proteomics, and microbial genomics perspective, respectively. We generally described the progress of brain imaging networks, gene networks, protein networks and micro biological networks in schizophrenia to increase our understanding of knowledge in this field. Key words: Schizophrenia; Brain connectomes; Genomics; Proteomics; Microbial genomics