Multiple Myeloma with the Primary Gastric Manifestation.

Jasiewicz Honkisz B

doi:10.4172/2165-7920.1000525

Abstract

Multiple myeloma is an immunoproliferative monoclonal disorder of plasma cells, characterized by an expansion of atypical cells, which produce monoclonal immunoglobulin. This neoplasm has several clinical presentations: solitary osseous plasmacytoma, plasmocytic leukemia or extramedullary plasmocytoma. Plasmocytoma are rare in the gastrointestinal tract. This case present a histologically confirmed case of primary gastric plasmocytoma.

Highlights

Multiple myeloma (MM) is an immunoproliferative monoclonal disorder of plasma cells, characterized by an expansion of atypical cells, which produce monoclonal immunoglobulin. It presents as a discrete, solitary mass of neoplastic monoclonal plasma cells in either bone or more rarely, soft tissue MM constitutes about 1% of all malignant neoplasms with morbidity in Europe reported to be 4,5/100000/year and 5-years survival is 35% [1]
Primary gastric extramedullary plasmocytoma (EMP) is diagnosed in elderly patients, but there are no typical symptoms
What important at the beginning there was only tumor in vertebral column, but recurrence was present in bone marrow and stomach [8]

Summary

Introduction

Multiple myeloma (MM) is an immunoproliferative monoclonal disorder of plasma cells (plasmocytoma), characterized by an expansion of atypical cells, which produce monoclonal immunoglobulin (protein M) It presents as a discrete, solitary mass of neoplastic monoclonal plasma cells in either bone (most frequently) or more rarely, soft tissue MM constitutes about 1% of all malignant neoplasms with morbidity in Europe reported to be 4,5/100000/year and 5-years survival is 35% [1]. Primary gastric plasmocytoma is an extremely rare presentation of all extramedullary plasmocytoma It constitutes 2-5% of EMCs. It constitutes 2-5% of EMCs This type of tumor was described first time in 1928 year by Vasiliu i Popa [5], and since that time about 100 of new cases have been described [6].

Discussion

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Conclusion