Abstract
Multiple myeloma (MM) is a neoplastic disorder originating from clonal proliferation of malignant plasma cells in the bone marrow microenvironment. MM is identified by the accumulation of differentiated B cells. The aim of this study is to report a case of a 65-year-old man presenting with a sessile swelling on the left palate measuring 8 cm in its largest diameter and covered by a necrotic membrane on the central surface area. Provisional clinical diagnosis included mucoepidermoid carcinoma and squamous cell carcinoma and an incisional biopsy was performed. Histologic analysis showed a diffuse proliferation of malignant cells with plasmablastic differentiation. Immunoreactions, bone marrow biopsy and systemic evaluation of the patient confirmed the diagnosis of MM. The patient was classified as stage 0 of the disease, underwent chemotherapy and use of thalidomide, and is under clinical control for 6 months. Multiple myeloma (MM) is a neoplastic disorder originating from clonal proliferation of malignant plasma cells in the bone marrow microenvironment. MM is identified by the accumulation of differentiated B cells. The aim of this study is to report a case of a 65-year-old man presenting with a sessile swelling on the left palate measuring 8 cm in its largest diameter and covered by a necrotic membrane on the central surface area. Provisional clinical diagnosis included mucoepidermoid carcinoma and squamous cell carcinoma and an incisional biopsy was performed. Histologic analysis showed a diffuse proliferation of malignant cells with plasmablastic differentiation. Immunoreactions, bone marrow biopsy and systemic evaluation of the patient confirmed the diagnosis of MM. The patient was classified as stage 0 of the disease, underwent chemotherapy and use of thalidomide, and is under clinical control for 6 months.
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