Abstract
Background: Multiple myeloma (MM) is a cancer of bone marrow (BM) that is caused by the clonal plasma cells which produce monoclonal immunoglobulin that cause manifestation such as hypercalcemia, pathological bone fracture, renal impairment, BM deficiency, and hyper viscosity. Interleukin 10 (IL-10) has anti-inflammatory effects by binding to IL-10R dependent signals on cell surface; if IL‐10 mutation affects cancer immunity so may be cause of many cancers including hematologic malignancies. Objective: To investigate role of IL-10 gene promoter (rs1800872) and its receptor beta (rs2834167) genotypes in (MM) patients on clinical presentation, laboratory findings, treatment response and outcome in a group of MM patients in Egyptian patients. Patients and Methods: The present study included 50 MM patients compared to 50 matched healthy individuals in age and sex with normal laboratory findings as a control group for analysis of single nucleotide polymorphisms (SNP) of IL-10 gene promoter (rs1800872), and IL‐10Rβ (rs2834167) genotypes using Real time- Polymerase Chain reaction (RT-PCR) technique. Results: The genotypes frequency distribution of IL-10 SNP (rs1800872), there was statistically significant difference between MM patient and the control groups (P- value 0.003) but not found as regard IL-10 RB (P –value 0.142).
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