Abstract
Amyloid is an extracellular proteinaceous deposited material that can be associated with continuous overproduction of acute-phase proteins in chronic inflammation or with abnormal immunoglobulin light chains in multiple myeloma. In this report, we describe an original case of amyloidosis affecting the oral cavity of a 77-year-old male patient that was under chemotherapy and zoledronic acid treatment because of a previously diagnosed multiple myeloma. The patient demonstrated multiple asymptomatic nodules in the tongue with 3 weeks’ duration that microscopically revealed a diffuse deposition of a homogeneous, eosinophilic material, which predominated around blood vessels and salivary gland acini. Congo red histochemical reaction was positive and the final diagnosis of oral amyloidosis secondary to multiple myeloma was done. The patient is currently under chemotherapy and free of any lesions in the oral cavity.
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