Abstract
Multiple myeloma (MM) is a clonal proliferation of plasma cells in the bone marrow resulting in the production of paraproteins. It is more common in elderly adults and presents with nonspecific symptoms like bone pain, pathological fracture, fatigue, and signs of hypercalcemia. Peripheral neuropathy is an atypical presentation. We present a rare case of vasculitic neuropathy (VN) who was also diagnosed with MM at the same time. Nerve conduction study and biopsy showed findings suggestive of demyelinating VN. His serum protein electrophoresis and bone marrow aspirate were consistent with MM. The association between these two conditions remains understudied. So far there is no strong evidence suggesting an association between MM and VN. If VN was just coincidental or a presenting symptom of MM remains a question and warrants further studies.
Highlights
Multiple myeloma (MM) is a monoclonal gammopathy characterized by the proliferation of clonal plasma cells within the bone marrow
We present a rare case of vasculitic neuropathy (VN) who was diagnosed with MM at the same time
We present a case of a patient who presented with symptoms of neuropathy and histopathology showed vasculitic neuropathy (VN), he was diagnosed with MM at the same time
Summary
Multiple myeloma (MM) is a monoclonal gammopathy characterized by the proliferation of clonal plasma cells within the bone marrow. The plasma cells exceed 10% of all bone marrow cells leading to an abnormal increase in clonal paraproteins which causes specific end-organ damage and acts as a disease marker [1] It accounts for 1.8% of all new cancer cases and 2.1% of cancer deaths in the United States [2]. We present a case of a patient who presented with symptoms of neuropathy and histopathology showed vasculitic neuropathy (VN), he was diagnosed with MM at the same time. Weakness first started in the right upper limb, on left upper limb, and started on bilateral lower limbs and was associated with a tingling sensation. He reported intermittent fever and weight loss for two months. The definitive chemotherapy with bortezomib, dexamethasone, and thalidomide regimen was planned, and the induction phase was initiated
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