Multiple Myeloma and Solid Tumors – a Frequent Rarity –

Abstract

Objective: Multiple Myeloma is defined by the proliferation of monoclonal B leukocytes (plasmacytes) in the bone marrow, which results in the production of monoclonal proteins into the urine or blood. With the development of novel therapies, the management of multiple myeloma has improved over time. However, an increasing number of patients now present with a history of solid tumors related to myeloma, which may be observed during the course of the patient's therapy. Case presentation: We present the case of a 53-year-old man who was referred to our department for additional testing to distinguish between multiple myeloma and bone metastases. The patient had a personal history of colonic cancer, which was diagnosed 5 months prior, and osteolytic lesions discovered on the abdominal CT scan. Increased atypical plasmocytic cells were observed in the bone marrow biopsy, and serum IgG kappa monoclonal protein were also positive. Conclusion: The case highlights the potential for concurrent hematologic and solid cancer coexistence.