Multiple medications and vehicle crashes: Analysis of databases

Abstract

Using population databases, this study analyzed the association of the impairing effects of multiple medication use, drug interactions, and drug disease interactions on motor vehicle crashes (MVCs) in individuals age 50 years and greater. The main objectives of this study were to determine the relative frequency of various combinations of medications used by those who have experienced a MVC and those who have not by analyzing proprietary and non-proprietary databases; and to conduct a case-control study of possible associations between the use of medications (and combinations thereof) and MVCs among older drivers. The results of this analysis suggest that both the kinds and number of medication exposures, and the characteristics of diseases/disorders present among study subjects may predict an increase in risk for MVCs among older adults. By demonstrating a potential link between multiple drug therapies and MVCs, this study serves to highlight the need for a more thorough examination of the relationships between drugs, diseases and the older driver. The study suggests the need for further research to elucidate the complex interplay of factors affecting aging adults and driving ability. The results of this research support the intentions of the National Highway Traffic Safety Administration to promote the development of educational programs to increase awareness among health care providers and older drivers regarding the potential driver impairing effects of pharmaceutical use.