Abstract
The antidepressant amoxapine has been linked to QT prolongation, acute heart failure, and sudden death. Drug binding to cardiac hERG (Kv11.1) potassium channels causes prolonged repolarization and induces apoptosis. This study was designed to investigate amoxapine effects on hERG currents, hERG protein trafficking, and hERG-associated apoptosis in order to elucidate molecular mechanisms underlying cardiac side effects of the drug. hERG channels were expressed in Xenopuslaevis oocytes and HEK 293 cells, and potassium currents were recorded using patch clamp and two-electrode voltage clamp electrophysiology.
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