Abstract
HIV-1 protease, because of its sensitive and essential function, is an excellent target for the drug therapy. The primary chain of an aspartic protease has two different Asp-Thr-Gly sequences. The MLR approach attempts to identify and quantify the physicochemical properties of the drug and to see whether any of these properties has any effect on drug’s biological activity. In present study 15 protease derivatives have been used as study material and on the basis of MLR equation their activity has been predicted.
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