Multiple Hepatic and Pulmonary Tumors Combined with Bilateral Adrenal Masses in a Young Woman with von Hippel–Lindau Disease

Abstract

Question: A 37-year-old woman was admitted to our center for adrenal diseases with bilateral adrenal tumors and multiple hepatic and pulmonary lesions for surgery. She was first diagnosed with von Hippel–Lindau (VHL) syndrome in April 2000, with proof of heterozygous point mutation c.292T>C in exon 1 of the VHL gene. Her father was diagnosed with a VHL gene mutation as well. She complained of a 4- to 5-kg weight loss in 4 months, increased daytime fatigue, and anxiety. She reported occasional nicotine abuse in the past.