Multiple genetic variations of chronic rhinosinusitis with nasal polyps are associated with respiratory parameters in men with obstructive sleep apnea

Qianqian Zhang,Xinyi Li,Weitian Zhang,Xiaoting Wang,Hongliang Yi,Xiangyu Cheng,Yunhai Feng,Haibo Ye,Huajun Xu,Huaming Zhu,Xiaolin Wu

doi:10.1007/s11325-021-02356-6

Abstract

PurposePatients with chronic rhinosinusitis with nasal polyps (CRSwNP) have a higher risk of obstructive sleep apnea (OSA). However, the relationship between CRSwNP and OSA remains unclear. The aim of this research study was to evaluate the association of multiple single nucleotide polymorphism (SNP) variations in CRSwNP with sleep- and breath-related parameters in men with OSA.MethodsWe included eight CRSwNP SNPs in 2320 participants after strict screening. For each participant, the genetic risk score (GRS) was calculated based on the cumulative effect of multiple genetic variants of CRSwNP. A bivariate correlation analysis was used to assess the relationship between CRSwNP genetic polymorphisms and polysomnography parameters in men with OSA. Logistic regression analyses were used to assess the relationship between the risk of OSA and CRSwNP genetic polymorphisms.ResultsIn moderate OSA, rs28383314 was related to the oxygen desaturation index, and rs4807532 was positively associated with the microarousal index (r = 0.09, P = 0.03 and r = 0.11, P = 0.01, respectively). The CRSwNP GRS was positively correlated with the oxygen desaturation index and cumulative time percentage with SpO2 < 90% in moderate OSA (r = 0.13, P < 0.001 and r = 0.1, P = 0.01, respectively). There was no association between the CRSwNP GRS and the risk of OSA (OR = 1.007; 95% CI, 0.973–1.042; P = 0.702).ConclusionIn men with moderate OSA, single CRSwNP genetic variations correlated with sleep-related parameters, and the cumulative effects of CRSwNP genetic variations were associated with the hypoxic index. CRSwNP may be a predisposing condition for sleep disorders in men with moderate OSA.

Highlights

Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder affecting 49.7% of men and 23.4% of women and is characterized by fragmented sleep, frequent episodes of upper airway collapse, and intermittent hypoxia [1, 2]
In men with moderate obstructive sleep apnea (OSA), single chronic rhinosinusitis with nasal polyps (CRSwNP) genetic variations correlated with sleep-related parameters, and the cumulative effects of CRSwNP genetic variations were associated with the hypoxic index
A study on an adult population from France showed that sleep and quality of life were negatively associated with CRSwNP, and patients attributed moderate and severe sleep disturbance to nasal obstruction caused by CRSwNP [24]

Summary

Introduction

Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder affecting 49.7% of men and 23.4% of women and is characterized by fragmented sleep, frequent episodes of upper airway collapse, and intermittent hypoxia [1, 2]. Sleep quality is known to be affected in individuals with chronic rhinosinusitis, and these patients have a higher risk of developing OSA [5, 6]. Another study showed a reduction in the risk of OSA and an improvement in sleep quality after surgery [11]. These findings indicate a close relationship between OSA and CRSwNP; the inherent link between OSA and CRSwNP has not yet been elucidated

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