Abstract
The measurement of serum alkaline phosphatase (EC 3.1.3.1 ALP) has been popular in clinical practice for over 50 years despite a limited knowledge of the structure, function and pathophysiology of this enzyme family. The existence of multiple forms of the enzyme has provided a great deal of opportunity for research and this has helped to refine ideas on the clinical utility of measurement of the enzymes in serum as well as to elucidate their structure and function. 1,2
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