Abstract
Migration Stimulating Factor (MSF) is an oncofetal regulatory molecule, constitutively expressed by various cell types during fetal development, generally not expressed by their counterparts in healthy adult tissues, but re-expressed during cancer progression. The diverse bioactivities of MSF, including its potent stimulation of cell migration/invasion, matrix remodelling and angiogenesis, suggest that it makes a significant contribution to driving tumour progression. In this review, we discuss the role of MSF within the general perspective of perturbed tumour cell-fibroblast interactions in cancer pathogenesis and its potential utility as a novel clinical target for improved patient management.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
