Abstract
Multiple Factors Involved in Nonalcoholic Hepatitis Pathogenesis
Highlights
In the “two-hit theory” model, fatty acids and triglycerides accumulate in the liver, leading to inflammation, oxidative stress, and mitochondrial dysfunction, causing liver damage
Nonalcoholic fatty liver disease (NAFLD) is the most common type of liver disease, with etiologies as varied as its presentations. This special issue of the International Journal of Hepatology examines some of the multiple factors involved in the pathogenesis of this chronic liver condition, ranging from inflammation, aberrant lipid metabolism, drug-induced liver injury, and babesiosis
NAFLD is marked by dysfunctional cholesterol metabolism, with cholesterol accumulation taking place as a result of de novo synthesis and plateauing excretion observed even if dietary intake is high
Summary
In the “two-hit theory” model, fatty acids and triglycerides accumulate in the liver, leading to inflammation, oxidative stress, and mitochondrial dysfunction, causing liver damage. Nonalcoholic fatty liver disease (NAFLD) is the most common type of liver disease, with etiologies as varied as its presentations. This special issue of the International Journal of Hepatology examines some of the multiple factors involved in the pathogenesis of this chronic liver condition, ranging from inflammation, aberrant lipid metabolism, drug-induced liver injury, and babesiosis. Shimizu (2012) describe the role of natural killer T (NKT) cells in NAFLD pathogenesis.
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