Year-end Sale % OFF 
Abstract
IntroductionEarly onset and high prevalence of allergic diseases result in high individual and socio-economic burdens. Several studies provide evidence for possible effects of environmental factors on allergic diseases, but these are mainly single-exposure studies. The exposome provides a novel holistic approach by simultaneously studying a large set of exposures. The aim of the study was to evaluate the association between a broad range of prenatal and childhood environmental exposures and allergy-related outcomes in children. Material and MethodsAnalyses of associations between 90 prenatal and 107 childhood exposures and allergy-related outcomes (last 12 months: rhinitis and itchy rash; ever: doctor-diagnosed eczema and food allergy) in 6–11 years old children (n = 1270) from the European Human Early-Life Exposome cohort were performed. Initially, we used an exposome-wide association study (ExWAS) considering the exposures independently, followed by a deletion-substitution-addition selection (DSA) algorithm considering all exposures simultaneously. All the exposure variables selected in the DSA were included in a final multi-exposure model using binomial general linear model (GLM). ResultsIn ExWAS, no exposures were associated with the outcomes after correction for multiple comparison. In multi-exposure models for prenatal exposures, lower distance of residence to nearest road and higher di-iso-nonyl phthalate level were associated with increased risk of rhinitis, and particulate matter absorbance (PMabs) was associated with a decreased risk. Furthermore, traffic density on nearest road was associated with increased risk of itchy rash and diethyl phthalate with a reduced risk. DSA selected no associations of childhood exposures, or between prenatal exposures and eczema or food allergy. DiscussionThis first comprehensive and systematic analysis of many environmental exposures suggests that prenatal exposure to traffic-related variables, PMabs and phthalates are associated with rhinitis and itchy rash.
Highlights
Onset and high prevalence of allergic diseases result in high individual and socio-economic burdens
Six existing longitudinal population-based European birth cohorts were included in the Human Early-Life Exposome (HELIX) project: the Born in Bradford (BiB) study (UK) (Wright et al 2013), the Étude des Déterminants pré et postnatals du development et de la santé de l’Enfant (EDEN) (France) (Heude et al 2016), the INfancia y Medio Ambiente (INMA) cohort (Spain) (Guxens et al 2012), the Kaunus cohort (KANC) (Lithuania) (Grazuleviciene et al 2009), the Norwegian Mother, Father and Child Cohort Study (MoBa) (Norway) (Magnus et al 2016) and the RHEA Mother Child Cohort study (Greece) (Chatzi et al 2017)
Based on the final multiexposure models our results suggest that prenatal exposure to inverse distance to nearest road and di-isononyl phthalate (DiNP), which is the parent compound of the metabolite oxo-MiNP, are associated with an increased risk of rhinitis, whereas exposure to particulate matter absorbance (PMabs) is associated with decreased risk
Summary
Onset and high prevalence of allergic diseases result in high individual and socio-economic burdens. The aim of the study was to evaluate the association between a broad range of prenatal and childhood environmental exposures and allergy-related outcomes in children. Material and Methods: Analyses of associations between 90 prenatal and 107 childhood exposures and allergy-related outcomes (last 12 months: rhinitis and itchy rash; ever: doctor-diagnosed eczema and food allergy) in 6–11 years old children (n = 1270) from the European Human Early-Life Exposome cohort were performed. Discussion: This first comprehensive and systematic analysis of many environmental exposures suggests that prenatal exposure to traffic-related variables, PMabs and phthalates are associated with rhinitis and itchy rash. In European children, the prevalence of these diseases are high (rhinitis: 9–23%; itchy rash; about 15%; eczema: 8–35% ; food allergy: 1–16%) (Austin et al 1999, Garcia-Aymerich et al 2015, Gupta et al 2007, Mallol et al 2013, Prescott et al 2013, Williams et al 1999). The steep increase in prevalence of these diseases the last decades (Platts-Mills 2015) has been too rapid to be induced only by changes in the underlying genetic susceptibility of the population
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
