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Abstract
Abstract Using a water-in-oil-in-water multiple emulsion system developed for pulmonary drug targeting, the effectiveness of tetrandrine as an antifibrotic agent and the therapeutic advantage of a tetrandrine emulsion over drug in solution for the treatment of silicosis were investigated in rats. Previously we have shown that the action of tetrandrine is attributed to its ability to inhibit the release of reactive oxygen metabolites and inflammatory cytokines by alveolar macrophages, and that targeted delivery of tetrandrine to alveolar macrophages using a multiple emulsion system minimizes drug toxicity, maintaines the drug's pharmacological activity, and enhances tetrandrine distribution in the lungs while reducing systemic drug distribution. The purpose of the present study is to provide in vivo evidence of emulsion-mediated enhancement of drug action in the lungs against silica-induced lung injury using a rat model. The antifibrotic action of tetrandrine was evaluated by examinations of lung histology...
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