Abstract
Abstract γ-Resorcylic acid inhibited glutamic-pyruvic and glutamic-oxaloacetic transaminase activities in extracts of rat liver, kidney, brain and heart. Its effects on the distribution of radioactivity from [3-14C] pyruvate among the soluble metabolic intermediates of chopped preparations of the rat tissues were consistent with this interference with transaminase enzymes. However, when [14C] glucose and [1,4-14C] succinate were incubated with isolated mitochondria and with a soluble fraction prepared from rat liver, the resorcylic acid produced marked changes in the incorporation of the radiocarbon into malic acid and fumaric acids, into an oligosaccharide fraction and into various phosphate compounds concerned in glycolytic reactions
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