Abstract
The effects of the differentiation inducing factor (DIF) on several cAMP-induced responses in Dictyostelium were investigated. It was found that DIF reduces the apparent affinity of cell-surface cAMP receptors. DIF does not affect the cAMP-induced cGMP response, but it is a potent inhibitor of the cAMP-relay response. DIF also inhibits the induction of prespore differentiation by cAMP in aggregation-competent cells. We also compared the effects of DIF on cAMP-induced responses with those of the relay inhibitor, caffeine, and the morphogen, adenosine.
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