Abstract
GASTROINTESTINAL STROMAL TUMORS (GISTS) are the most common mesenchymal tumors of the gastrointestinal tract. Type 1 neurofibromatosis (von Recklinghausen disease) is known to be associated with GIST. A 56-year-old man with no previous medical history presented with epigastric pain and anemia. The clinical examination showed multiple subcutaneous nodes in the trunk. The upper gastrointestinal endoscopy revealed two submucosal tumors of 20 and 8 mm in the second part of the duodenum, whichnarrowed the lumen andwas associatedwith 2 additional lesions of less than 1 cm in the third part of the duodenum. Endoscopic ultrasonography confirmed these multiple submucosal duodenal tumorswithout involvement of themucosa.Multiple nonspecific lymph nodes surrounded the duodenum.At biopsy, fusiformcells, suggestingGIST, were found. The colonoscopy was unremarkable, as was the thoracoabdominal CT scan.
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