Abstract
ObjectiveTo compare 2 different methods—multiple doses of misoprostol and a combination of misoprostol and oxytocin—for termination of pregnancy in the second trimester. MethodsBetween 2006 and 2008, 120 women undergoing termination of second-trimester pregnancy in 2 hospitals in Kermanshah, Iran, were enrolled in a randomized trial comparing 2 treatments. In each treatment group, an initial vaginal dose of 600μg of misoprostol was placed in the posterior fornix. After 6hours, an intravenous infusion of concentrated oxytocin was given to women in group A, and 400μg of vaginal misoprostol was given every 6hours to women group B, up to a maximum of 4 doses. The outcomes were compared via χ2 and independent t tests. ResultsWithin 30hours, 96.7% of women in group A and 96.7% of women in group B delivered successfully. The average duration between induction and delivery time was 12.3±6.0hours in group A and 12.1±6.0hours in group B (P>0.05). ConclusionThe use of misoprostol with oxytocin, and multiple doses of misoprostol gave similar results for termination of pregnancy in the second trimester.
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