Abstract
Dietary supplements are widely used for health purposes. However, little is known about the metabolic and cardiovascular effects of combinations of popular over-the-counter supplements, each of which has been shown to have anti-oxidant, anti-inflammatory and pro-longevity properties in cell culture or animal studies. This study was a 6-month randomized, single-blind controlled trial, in which 56 non-obese (BMI 21.0-29.9 kg/m(2)) men and women, aged 38 to 55 yr, were assigned to a dietary supplement (SUP) group or control (CON) group, with a 6-month follow-up. The SUP group took 10 dietary supplements each day (100 mg of resveratrol, a complex of 800 mg each of green, black, and white tea extract, 250 mg of pomegranate extract, 650 mg of quercetin, 500 mg of acetyl-l-carnitine, 600 mg of lipoic acid, 900 mg of curcumin, 1 g of sesamin, 1.7 g of cinnamon bark extract, and 1.0 g fish oil). Both the SUP and CON groups took a daily multivitamin/mineral supplement. The main outcome measures were arterial stiffness, endothelial function, biomarkers of inflammation and oxidative stress, and cardiometabolic risk factors. Twenty-four weeks of daily supplementation with 10 dietary supplements did not affect arterial stiffness or endothelial function in nonobese individuals. These compounds also did not alter body fat measured by DEXA, blood pressure, plasma lipids, glucose, insulin, IGF-1, and markers of inflammation and oxidative stress. In summary, supplementation with a combination of popular dietary supplements has no cardiovascular or metabolic effects in non-obese relatively healthy individuals.
Highlights
Non-vitamin, non-mineral dietary supplements are widely used for health purposes and sometimes as a substitute to a healthy diet or conventional medical treatments
The present study was a randomized clinical trial to evaluate the effectiveness of supplementation with a combination of some of the most self-prescribed dietary supplements, in www.impactaging.com
We evaluated the combined effects of these supplements on arterial stiffness, endothelial function, markers of inflammation, oxidative stress, glucose and lipid metabolism, and blood pressure
Summary
Non-vitamin, non-mineral dietary supplements are widely used for health purposes and sometimes as a substitute to a healthy diet or conventional medical treatments. It has been reported that these compounds exert powerful protective effects against inflammation, oxidative stress/free radical damage, insulin resistance, and protein glycation in cell culture and laboratory animal studies [3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24]. We evaluated the combined effects of these supplements on arterial stiffness, endothelial function, markers of inflammation, oxidative stress, glucose and lipid metabolism, and blood pressure
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have