Multiple Cutaneous Leiomyomas

Abstract

Cutaneous leiomyomas are uncommon tumors that arise from arrector pili (pilar leiomyoma), genital smooth muscle (genital leiomyoma), or vascular smooth muscle (angioleiomyoma). As multiple lesions, they may occur in association with uterine leiomyomas and, rarely, leiomyosarcomas, in the multiple cutaneous and uterine leiomyomatosis (MCUL) syndrome. More recently, cutaneous and uterine leiomyomas have been reported to occur in association with renal cell carcinoma in the hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome. MCUL and HLRCC likely represent part of a spectrum of one disease.