Abstract
Breast angiosarcomas (BAs) are rare but serious events that may arise after radiation exposure. Disease outcome is poor, with high risk of local and distant failure. Recurrences are frequent also after resection with negative margins. The spectrum of vascular proliferations associated with radiotherapy in the setting of breast cancer has expanded, including radiation-associated atypical vascular lesions (AVLs) of the breast skin as a rare, but well-recognized, entity. Although pursuing a benign behavior, AVLs have been regarded as possible precursors of postradiation BAs. We report an unusual case of a 71-year-old woman affected by well-differentiated bilateral cutaneous BA, diagnosed 1.9 years after adjuvant RT for synchronous bilateral breast cancer. Whole-life clinical followup is of crucial importance in breast cancer patients.
Highlights
The spectrum of vascular proliferations associated with radiotherapy in the setting of breast cancer has expanded, including radiation-associated atypical vascular lesions (AVLs) of the breast skin as a rare, but well-recognized, entity
We report an unusual case of a 71-year-old woman affected by welldifferentiated bilateral cutaneous Breast angiosarcomas (BAs), diagnosed 1.9 years after adjuvant RT for synchronous bilateral breast cancer
Angiosarcomas (ASs) are rare malignant tumors that arise from endothelial cells lining vascular channels [1, 2]
Summary
Angiosarcomas (ASs) are rare malignant tumors that arise from endothelial cells lining vascular channels [1, 2]. They account for less than 1% of all soft tissue sarcomas and occur in all organs of the body. Secondary BAs are usually found in older women at the site of radiotherapy (RT) for breast cancer (BC). They typically involve the dermis and present with skin changes that can be misinterpreted even with benign conditions such infection [5]. Diagnosed 1.9 years after adjuvant RT for synchronous bilateral BC
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