Abstract
In 1962, Degos et al<sup>1</sup>described an uncommon benign skin tumor, histologically identifiable by sharply demarcated, regular acanthosis. They named it clear cell<i>acanthoma</i>. Under microscopic examination, the tumor was found to consist of pale epidermal cells containing abundant amounts of glycogen, as evidenced by PAS-positive and diastase labile stains. Further clinical and histologic characterization followed publication of this report.<sup>2,3</sup> The acanthoma arises as an asymptomatic, single, erythematous papule or plaque, measuring 5 to 10 mm in diameter. It occurs in both sexes, usually in midlife. It most commonly appears on the lower part of the leg, especially on the calf. A fine, scaly layer may cover the tumor, which blanches on diascopy and bleeds easily with minor trauma, mimicking a pyogenic granuloma. The solitary clear cell acanthoma is an uncommon tumor. Multiple lesions, however, are truly rare, with only 12 cases reported to date. We report herein
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