Multiple-Balloon-Kymograph Recording of Variations in Motility of the Upper Small Intestine in Man During Long Observation Periods Before and After Placebo Administration

Abstract

Summary 1.Fourteen observations have been made of the variations in motility of the upper small intestine in 12 adult subjects. Motor activity was recorded graphically with a multiple-balloon water manometer system for an average period of four hours. Placebos were given without verbal suggestion after an average control period of 48 minutes. 2.After administration of placebos propulsive and total contractions were found to decrease on an average of 32 per cent and 24 per cent, respectively, with the passage of time. From one 15-minute period to another the mean tone levels varied less than did the levels of contractile activity. Tone both increased and decreased and in some instances remained essentially unchanged. 3.Spasms or temporary sudden elevations of tone were associated with both temporary and prolonged decreases in contractions. 4.The character of the motility pattern was often fairly constant for a given individual. 5.With one exception, it was felt that any downward movement of the tube during the experiments was not an important factor in determining the changes in motility which were observed. 6.These results have been useful as control data in estimating the effect of drugs on the motility of the upper small intestine.