Abstract
MAIS is a rare entity, characterised by a combination of several autoimmune disorders. It is divided into three groups. Biermer disease (BD) belongs to MAIS 3 and is an autoimmune atrophic gastritis causing vitamin B12 deficiency, often associated with autoimmune diseases. The most frequently described are endocrinopathies, dominated by autoimmune thyroiditis followed by type 1 diabetes. Others have been reported, such as vitiligo, Gougerot-Sjögren syndrome and systemic lupus erythematosus. The coexistence of Biermer disease, AHAI or Biermer disease, primary biliary cirrhosis (PCB) and immunological thrombocytopenicpurpura (ITP) is rare. The diagnosis of Biermer's disease therefore requires systematic screening for other autoimmunedisorders. Keywords: multiple autoimmune syndrome, Biermer disease, autoimmunity, atrophicgastritis, replacement therapy.
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