Multiple and Combinatorial Peptide Synthesis

Abstract

AbstractThe rapid synthesis of peptides to support both exploratory peptide lead discovery and analog structure-activity studies has been the subject of intense research and technology development over the past few years (1– 4). Two general approaches have been advanced that may be classified as follows: (1) multiple peptide synthesis (MPS) and (2) combinatorial peptide synthesis (CPS). The peptide chemistry aspect of such multiple or combinatorial approaches typically integrates experimental methodologies that have been well established to date for the preparation of single peptides by solid-phase techniques. However, there exist novel and, in some cases, proprietary chemistry methods and/or materials that are essential to each of these approaches (vide infra). A common objective of the multiple or combinatorial approaches is to expedite the process and quantitative scope of synthetic peptide production in a manner that interfaces well with biological testing.KeywordsPeptide LibraryResin BeadComponent PeptideSimultaneous CouplingSingle Reaction VesselThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.